Introduction

Our research focuses on different aspects of protein design, how proteins fold and how large protein complexes assemble. Projects cover diverse areas such as biophysics, molecular biology (including protein engineering) and chemical biology.

Current projects include:

• Protein Folding:
• • Single molecule studies on the folding of ubiquitin
  • How co-operative is the folding of a large beta-barrel protein? - Studies on GFP mutants
  • Stability and folding studies of Ubiquitin in the cellular environment.
• Untangling the Folding Kinetics of Knotted Proteins:
• • Studies on YibK and YbeA
  • Studies on UCH-L3 and UCH-L1
• Protein Complex Assembles:
• • How do molecular chaperones work to assemble large molecular complexes?
  • Hsp90 and the proteins it associates with.